产后母亲吸烟是子女胃肠道疾病的危险因素:孟德尔的随机化研究
Shuai Wang1, Tao Zhang1, Dongming Li1
1Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Digestive diseases and sciences
|January 22, 2025
概括
母亲在出生前期吸烟 (MSAB) 会增加后代患上胃肠道疾病的风险,如炎症性肠病 (IBD) 和胃潰瘍. 建议对孕妇在怀孕期间吸烟的孩子增加健康监测.
科学领域:
- 遗传学和流行病学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 母亲在出生前期吸烟对后代胃肠道疾病的影响仍然不完全理解.
- 现有的研究还没有完全阐明MSAB和各种GI疾病之间的因果关系.
研究的目的:
- 通过强大的孟德尔随机化 (MR) 方法,研究基因预测母亲在出生前期吸烟 (MSAB) 与后代24种不同的胃肠道疾病之间的关联.
- 为了确定与MSAB有因果关系的后代的特定GI疾病.
主要方法:
- 使用了两个样本的门德尔随机化 (TSMR) 研究设计.
- 从大型遗传数据库 (FinnGen) 采用与MSAB和GI疾病相关的单核酸多态 (SNPs).
- 应用逆方差权衡 (IVW) 和灵敏度分析,包括错误发现率 (FDR),以确保结果的准确性和稳定性.
主要成果:
- 基因决定的MSAB与后代的胃肠道疾病风险增加显著相关 (OR 1.251;P < 0.001).
- 对MSAB的遗传倾向与五种特定的胃肠道疾病的更高风险有关:食道,胃肠,炎症性肠病 (IBD) 和性结肠炎 (UC).
结论:
- 基因预测的MSAB被证实是几种后代胃肠道疾病的危险因素,特别是IBD,UC和胃潰瘍疾病.
- 强调需要加强妊娠期间吸烟母亲后代的健康监测,以检查胃肠道疾病.
- 强调需要进一步研究将MSAB与肠道疾病发展联系在一起的潜在生物机制.
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