已知的机制无法解释非黄金色的葡萄糖球菌中三分之一的敏感性降低
Heather Felgate1,2, Lisa C Crossman1,3,4, Elizabeth Gray1
1Medical Microbiology Research Laboratory, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, NR4 7UQ, UK.
npj antimicrobials and resistance
|January 22, 2025
概括
非光性葡萄球菌 (NAS) 显示出有关抗菌素耐药性的迹象,许多分离体对多种药物具有耐药性. 这突显了它们在医疗保健感染中的潜在作用,以及作为抗药性基因的储存库.
科学领域:
- 临床微生物学 临床微生物学
- 抗微生物耐药性 抗微生物耐药性
- 基因组学就是基因组学.
背景情况:
- 在医疗保健相关的感染中,越来越多地发现非黄金色葡萄球菌 (NAS).
- 了解NAS抗菌素耐药性 (AMR) 对临床管理和跟踪耐药性基因储存至关重要.
研究的目的:
- 为了评估抗菌素耐药性的流行率和遗传基础,在一个多样化的非紫色葡萄球菌 (NAS) 孤立的集合.
- 调查在NAS中缺乏认可的AMR负担,特别是针对临床相关的抗微生物药物.
主要方法:
- 从各种来源 (临床,人类,动物,类型培养) 收集了394个NAS分离物.
- 对八种抗微生物进行了抗微生物敏感性测试,包括对甲基西林耐药性进行查.
- 在366个分离物体上进行了全基因组测序,以确定遗传抵抗机制.
主要成果:
- 175个隔离物显示对素的敏感性降低,其中50%缺乏已知的素同类物质.
- 八个临床NAS隔离体表现出高达普托MIC,没有发现的耐药性机制.
- 49%的所有分离物体对三种或更多抗微生物药物的敏感性降低.
- 抗红素耐药性与特定的基因 (msrA, ermC) 有关.
结论:
- 在NAS中广泛减少的抗微生物敏感性是一个重大问题.
- NAS可能会导致难以治疗的感染,并作为抗药性基因的储存库,影响AMR检测和患者管理.
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