18-49岁成年人阶段角度和全因死亡率之间的关联:NHANES 1999-2004年
Xian-Xin Xia1, Chuan-Xiang Li1, Xin-Xin Xue1
1Department of Respiratory and Critical Care Medicine, the Third Hospital of Wuhan, Wuhan, 430030, People's Republic of China.
Scientific reports
|January 22, 2025
概括
营养状况指标相角 (PhA) 与18-49岁成年人全因死亡率降低有关. 较高的PhA值显著降低死亡风险,特别是在非吸烟者中.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- 阶段角 (PhA) 是细胞完整性和营养状况的公认指标.
- 以前的研究已经确定了PhA与老年人全因死亡率之间的联系.
- 在年轻成年人 (18-49岁) 中,PhA与死亡率之间的关联仍未得到充分研究.
研究的目的:
- 调查阶段角 (PhA) 与18-49岁成年人全因死亡率之间的关系.
- 确定PhA是否可以作为这一人口群中死亡风险的预后标记.
- 探索PhA与吸烟等其他风险因素之间的潜在相互作用.
主要方法:
- 利用了来自国家健康和营养检查调查 (1999-2004) 的6338名年龄在18-49岁的成年人的数据.
- 使用卡普兰-梅尔曲线,多重考克斯回归和分层分析来评估死亡风险.
- 根据中位数值将参与者分为低 (PhA <6.96°) 和高 (PhA ≥6.96°) PhA组.
主要成果:
- 在214个月的中位数随访期间,共记录了307例因各种原因死亡.
- 低PhA组与高PhA组 (3.98%) 相比,具有较高的全因死亡率 (5.07%).
- 在完全调整后,更高的PhA显著与所有原因死亡率的降低有关 (HR=0.73,P=0.005),在非吸烟者中观察到更强的效应 (HR=0.62,P=0.003).
结论:
- 阶段角 (PhA) 与18-49岁成年人全因死亡率显著和负相关.
- 较高的相角值表明,在这个年轻的成年人群中,死亡风险较低.
- 在非吸烟者中,PhA与死亡率之间的保护性关联更为明显,这表明潜在的协同效应.
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