估计的葡萄糖处置率与代谢综合征患病率和死亡风险的关联:基于人口的研究
Xiaoli Chen1,2, Aihua Li1,2, Qilin Ma3,4
1Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha, Hunan, China.
估计的葡萄糖处置率 (eGDR) 与代谢综合征 (MetS) 密切相关,有效预测受影响个体的死亡风险. 与其他常见指数相比,eGDR显示出所有原因死亡率的优越预测能力.
科学领域:
- 代谢综合征研究 代谢综合征研究
- 心血管疾病流行病学
- 生物标志物发现发现
背景情况:
- 胰岛素抵抗 (IR) 是代谢综合征 (MetS) 的关键因素,也是心血管疾病 (CVD) 和死亡率的重要因素.
- 估计的葡萄糖排放率 (eGDR) 是IR的验证标志物,并且在心血管疾病中显示出预后价值.
研究的目的:
- 调查eGDR和MetS流行之间的关联.
- 评估eGDR在临床结果中的预测作用,包括所有原因和心血管疾病死亡率.
主要方法:
- 使用了NHANES数据 (2001-2018) 与横截面和队列设计.
- 使用加权后勤和考克斯比例危险模型进行关联和死亡率分析.
- 应用限制立方线 (RCS) 分析用于非线性关联和C-统计学用于预测性能的比较.
主要成果:
- 在eGDR和MetS患病率之间观察到显著的负相关性 (p < 0.001).
- 在患有MetS的个体中,更高的eGDR与每次SD增加的全因 (11%) 和心血管疾病 (18%) 死亡风险降低有关.
- 与TyG和HOMA-IR指数 (p = 0.007) 相比,eGDR显示出所有原因死亡率的优越预测能力.
结论:
- eGDR与MetS有着强烈的关联,并作为MetS患者全因和心血管疾病死亡率的重要预测因子.
- 对于全因死亡率,eGDR比TyG和HOMA-IR具有更强的预测效用,使其成为一种有价值的临床风险评估工具.
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