婴儿呼吸道病原体在COVID-19之前,期间和之后的非药物干预的变化在北京
Tongying Han1, Yajuan Wang2, Di Zhang1
1Department of Neonatology, Children's Hospital, Capital Institute of Pediatrics, Beijing, 100020, China.
在COVID-19期间的非药物干预 (NPI) 暂时减少了住院婴儿的呼吸道病原体检测. 在NPI后,病原体检测率和季节性分布发生了转变,突出显示了婴儿呼吸系统健康持续监测的必要性.
科学领域:
- 儿童传染病 儿童传染病
- 呼吸道病毒学 呼吸道病毒学
- 流行病学 流行病学
背景情况:
- 研究了COVID-19大流行期间实施的非药理干预措施 (NPI) 对北京住院婴儿 (0-3个月) 的呼吸道病原体概况的影响.
- 检查了COVID-19流行病前,期间和之后的病原体检测率和季节性的变化以及相关的NPI.
研究的目的:
- 确定COVID-19相关的NPI如何影响幼儿呼吸道病原体的类型和流行率.
- 了解NPI实施和随后取消后婴儿呼吸道病原体流行病学的转变.
主要方法:
- 从2018年1月至2023年12月期间,从1184名住院婴儿 (0-3个月) 获得急性呼吸道感染的呼吸道样本的回顾性分析.
- 根据COVID-19和NPI时间表将数据分为流行病前,流行病预防和控制和流行病后时期.
- 检测14种常见的呼吸道病原体,包括流感病毒,RSV,PIV,ADV,HRV,冠状病毒和SARS-CoV-2.
主要成果:
- 整体呼吸道病原体检测率为51.77%. 在疫情预防期间,检测率与疫情前期间相比显著增加.
- 疫情后,虽然总体阳性病例比例下降,但特定病原体的检测率显著增加,如A型流感,偏流感病毒和SARS-CoV-2.
- 观察到季节性分布的显著变化,在NPI终止后的第二,第三和第四季度检测率增加.
结论:
- 实施和取消COVID-19 NPI显著改变了住院婴儿呼吸道病原体的检测率和季节性模式.
- 在大流行期间,NPI暂时减少了病原体检测,但随后的变化需要持续监测,以制定有效的预防和控制策略.
- 了解这些流行病学转变对于管理脆弱婴儿群体的呼吸道疾病至关重要.
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