临床研究网络:JHCRN基础设施和经验教训
Rahul Kashyap1,2, Gayane Yenokyan1,3, Robert Joyner1,4
1Johns Hopkins Clinical Research Network, Baltimore, Maryland, USA.
Clinical and translational science
|January 23, 2025
概括
临床研究网络 (CRN) 提供了一个解决复杂临床研究的替代模型. 约翰霍普金斯大学临床研究网络 (JHCRN) 展示了成功的学术-社区合作伙伴关系,以加速研究.
科学领域:
- 临床研究方法论临床研究方法论
- 医疗服务研究 医疗服务研究
- 翻译科学是翻译的科学.
背景情况:
- 临床研究越来越复杂,导致成本上升,学习时间延长,招聘和通用性面临挑战.
- 临床研究网络 (CRN) 已经成为简化研究流程和吸引更广泛社区的模式.
- 约翰霍普金斯大学临床研究网络 (JHCRN) 成立于2009年,旨在促进学术医疗中心和社区卫生系统之间的多种疾病合作.
研究的目的:
- 报告约翰霍普金斯大学临床研究网络 (JHCRN) 的建立,结构和成果.
- 为了说明学术-社区伙伴关系如何在多种不同的医疗保健环境中促进临床研究.
- 分享开发和运营区域临床研究网络的经验教训.
主要方法:
- 建立了多种疾病的研究合作,涉及学术医疗中心和社区医院/卫生系统.
- 实施了中央集权治理结构,有一个单一的机构审查委员会 (IRB) 和一个专门的合同办公室.
- 在大西洋中部地区的九个卫生系统中,利用有组织的患者社区,基于社区的调查人员和学术研究人员.
主要成果:
- 进行了81项研究,包括临床试验,队列研究和比较有效性研究,由NIH,基金会和行业资助 (截至2024年8月).
- 促进了该地区不同规模和类型的医院之间的研究伙伴关系.
- 更好地了解参与站点和相关的门诊实践的复杂性.
结论:
- 临床研究网络,作为学术-社区伙伴关系,为多种疾病研究提供了必要的基础设施.
- CRN促进共享风险,增加调查人员的参与,并改善志愿者参与.
- 该JHCRN模型证明了扩大研究合作和加速临床研究交付的成功方法.
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