染色体10上的几种变异与大祖黑山羊 (Capra hircus) 的粗毛直径有关
Jipan Zhang1,2,3, Jiabei Fang1, Siyuan Zhang1
1College of Animal Science and Technology, Southwest University, Chongqing, China.
Animal genetics
|January 23, 2025
概括
这项研究确定了重要的基因组变异,包括单核酸多态 (SNPs) 和插入/删除 (indels),与山羊粗毛直径相关. 这些发现为纤维特征的遗传基础提供了洞察力.
科学领域:
- 动物遗传学动物遗传学
- 基因组学就是基因组学.
- 织科学 织科学
背景情况:
- 羊具有双层毛皮;外围粗毛提供保护,但与喀什米尔相比,它们的基因研究不足.
- 了解粗毛遗传学对于动物育种和织应用至关重要.
研究的目的:
- 为了确定与山羊粗毛直径相关的基因组变异 (SNP和indels).
- 通过全基因组关联研究 (GWAS) 确定影响粗毛变异的特定基因和基因组区域.
主要方法:
- 收集了263只成年雌山羊的粗毛和血液样本.
- 测量了粗毛的直径,并进行了全基因组测序.
- 在超过1100万个SNP和86万个indels上进行了全基因组关联研究 (GWAS).
主要成果:
- 确定了八个显著的SNP和三个与粗毛直径相关的显著的INDEL.
- 在4号染色体上位于COL28A1和C1GALT1附近的一个关键SNP.
- 在第10染色体 (chr10_96664101-96670958) 上发现了一个显著的基因组区域,其中包含了基因CDO1和TMED7,具有显著的indel.
结论:
- 鉴定的基因组变异和区域,特别是染色体10上的基因组变异和区域,对于了解山羊粗毛直径的遗传控制至关重要.
- 这些发现为未来研究纤维特征的遗传机制以及在山羊育种计划中使用标记器辅助的选择提供了基础.
相关概念视频
Pleiotropy
39.6K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
39.6K
Incomplete Dominance
21.2K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
21.2K
Epistasis
45.6K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
45.6K
Comparing Copy Number Variations and SNPs
17.1K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.1K
Genetic Lingo
100.5K
Overview
100.5K
Genome-wide Association Studies-GWAS
12.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.4K


