关于VEGF-2578C/A多态性与2型糖尿病视网膜病变敏感性之间的关联的元分析
1Fundus Disease Department, Ai'er Ophthalmology Hospital of Shangrao, Shangrao, Jiangxi, China.
Current eye research
|January 23, 2025
概括
血管内皮生长因子 (VEGF) -2578C/A多态性与2型糖尿病视网膜病变 (T2DR) 的风险增加有关. 具体来说,等位基因A和AA+CA基因型与更高的T2DR敏感性有关.
科学领域:
- 遗传学和眼科 医学
- 分子生物学分子生物学
- 医学研究 医学研究
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病患者视力丧失的主要原因.
- 遗传因素,包括血管内皮生长因子 (VEGF) 的多态性,都与DR的发展有关.
- 了解这些遗传关联可以帮助风险分层和2型糖尿病视网膜病变 (T2DR) 的个性化管理.
研究的目的:
- 研究血管内皮生长因子 (VEGF) -2578C/A多态性和对2型糖尿病视网膜病变 (T2DR) 的易感性之间的关联.
- 进行元分析,巩固这一遗传关联的证据.
主要方法:
- 在四个数据库中进行了系统的文献搜索,截至2024年7月.
- 用Stata 15.0软件进行了元分析.
- 分析包括了10篇文章,包括1390个病例和1306个控制.
主要成果:
- 在等位基模型 (A/C:OR=1.33,95%CI:1.04-1.72,p=0.025) 和主导模型 (AA+CA/CC:OR=1.38,95%CI:1.00-1.91,p=0.047) 下,VEGF-2578C/A多态性与T2DR风险有显著的关联.
- 在衰退型,同卵性或异卵性模型中没有发现显著的关联 (所有p>0.05).
结论:
- VEGF-2578C/A多态性与对2型糖尿病视网膜病变的易感性有关.
- 在VEGF-2578C/A位点的A基因组和AA+CA基因型与患T2DR的风险增加有显著联系.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...


