在次级渐进性多发性硬化症中的神经纤维重链
Floriana De Angelis1,2, Francesca Ammoscato3, Richard A Parker4
1Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, University College London Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
概括
大脑脊髓液 (CSF) 神经纤维重链 (NfH) 和神经纤维轻链 (NfL) 显示为追踪多发性硬化症 (MS) 进展的生物标志物具有前途. 这些CSF神经丝比血清标志物更好地预测疾病恶化.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 临床神经学 临床神经学
背景情况:
- 生物标志物对于监测多发性硬化症 (MS) 临床试验中的疾病进展至关重要.
- 由于测试的局限性,神经纤维重链 (NfH) 的利用不足.
研究的目的:
- 通过使用现代免疫试验,评估脑脊液 (CSF) NfH 在二级渐进性多发性硬化症 (SPMS) 的附加值.
- 为了比较CSF NfH和NfL作为SPMS中的生物标志物的实用性.
主要方法:
- 在MS-SMART试验中的探索性研究,涉及54名参与者.
- 在基线,48周和96周收集了临床数据,CSF和血清样本.
- 使用单分子阵列测定测量CSF和血清NfL和NfH;在基线和96周获得的大脑MRI.
主要成果:
- 基线CSF NfH和NfL与96周信息处理速度 (SDMT) 相相关,NfH显示的相关性比NfL (r = -0.37) 强 (r = -0.49).
- 基线CSF NfL预测手的灵敏度和大脑缩较差,而CSF NfH预测皮质灰质体积.
- 血清神经纤维素与临床结果的相关性有限.
结论:
- 在小型的SPMS研究中,CSF神经丝 (NfH和NfL) 优于血清神经丝.
- 脑脊流NfH和NfL可变地预测手部功能下降,认知障碍和大脑体积损失,可能反映出不同的神经退行途径.
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