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慢性肝病中小肠细菌过度生长:对病例控制研究的更新系统审查和元分析
Ayesha Shah1,2,3, Liam Spannenburg1,2, Parag Thite1,2
1Faculty of Medicine, University of Queensland, Australia.
EClinicalMedicine
|January 23, 2025
概括
小肠细菌过度生长 (SIBO) 在慢性肝病 (CLD) 患者中比在健康个体中更为普遍. 特别常见的是SIBO在CLD患者中出现并发症,如门高血压和自发性细菌周周炎.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 内部医学 内部医学
背景情况:
- 小肠细菌过度生长 (SIBO) 越来越被认为是慢性肝病 (CLD) 发展的一个因素.
- 在CLD患者中SIBO的确切患病率,特别是那些患有晚期肝病及其并发症的人,需要进一步阐明.
研究的目的:
- 系统地审查和分析慢性肝病 (CLD) 患者中SIBO患病率.
- 为了比较CLD患者和健康对照人群之间的SIBO患病率.
- 评估各种并发症的CLD患者的SIBO患病率,包括不补偿性肝硬化,门腔高血压和自发性细菌周周炎.
主要方法:
- 对病例控制研究进行了系统审查和元分析.
- 在电子数据库中搜索到2024年7月为在CLD患者中报告SIBO的研究.
- 使用随机效应模型计算了流行率和赔率比率 (OR).
主要成果:
- 分析包括34项研究,包括2130名CLD患者和1222名对照.
- 与对照组相比,CLD患者的SIBO几率显著更高 (OR = 6.7).
- 在非补偿性肝硬化,门腔高血压 (PHT) 和自发性细菌周周炎 (SBP) 的CLD患者中,SIBO患病率显著更高.
结论:
- 与健康个体相比,慢性肝病患者中SIBO的患病率明显高.
- 像PHT和SBP这样的并发症的存在进一步增加了CLD中的SIBO患病率.
- SIBO与CLD并发症密切相关,可能在疾病进展中发挥作用.
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