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吸烟和急性心肌梗塞的基因表达特征:血液转录组分析

Fang-Fang Liu¹, Yi-Xuan Yan², Hong-Feng Zhang¹

¹Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.

Mediators of inflammation

|January 23, 2025

概括

吸烟会改变血液中的基因表达,增加急性心肌梗塞 (AMI) 风险. 研究人员在血液中发现了关键基因,这些基因将吸烟与AMI联系起来,可能成为未来心血管健康的生物标志物.

科学领域:

心血管疾病研究研究
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

吸烟是心血管疾病的主要危险因素,如高血压和心肌梗塞 (MI).
连接吸烟与心血管疾病的确切分子机制尚不清楚.
了解这些联系对于制定预防和治疗策略至关重要.

研究的目的:

为了确定血液中共享的分子特征,这些特征将吸烟暴露与急性心肌梗塞 (AMI) 联系起来.
研究基因表达变化在吸烟相关心血管风险中的作用.

主要方法:

来自基因表达综合 (GEO) 数据库的七个血液转录组微阵列数据集的元分析 (403名患者).
与AMI和吸烟相关的差异表达基因 (DEGs) 的鉴定.
使用独立数据集和qRT-PCR的功能丰富分析和关键基因验证.

主要成果:

与AMI和吸烟相关的DEG在免疫反应和炎症途径中显著丰富.
三个基因 (PTGDR,PYHIN1,PRSS23) 在吸烟和AMI中显示出一致的改变.
在AMI中,PYHIN1和PRSS23的失调被qRT-PCR证实.

结论:

吸烟引起的血液基因表达变化可能会导致AMI风险.
这些已识别的基因 (PTGDR,PYHIN1,PRSS23) 涉及到AMI的发病过程.
这些基因可以作为血液基生物标志物用于吸烟者的心血管风险评估.

关键词:

剧烈的心肌梗塞急性心肌梗塞血液转录组 (blood transcriptome) 是一个细胞转录组.心血管生物标志物心血管生物标志物不同的基因表达.吸烟是为了吸烟.

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