在患有缺血性中风的患者中,淋巴细胞计数,白质过强度和脑缩之间的相关性
Chenchen Liu1, Dai Shi1, Xiaoqiong Ni1
1Department of Radiology, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Frontiers in aging neuroscience
|January 23, 2025
概括
在急性缺血性中风患者中,较高的淋巴细胞计数与白质过强度和脑缩的风险降低有关. 这表明炎症标志物可能会影响中风相关的大脑变化.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 炎症研究 炎症研究
背景情况:
- 白质高强度 (WMH) 和大脑缩是中风患者中脑小血管疾病 (CSVD) 的关键成像标志物.
- 这些标志物在中风后果方面具有显著的预后价值.
- 淋巴细胞计数是炎症的公认标志物.
研究的目的:
- 研究急性缺血性中风 (AIS) 患者的淋巴细胞计数和WMH和脑缩之间的关联.
主要方法:
- 分析了727名AIS患者的淋巴细胞计数和MRI数据.
- 根据基线淋巴细胞计数,患者被分为四分之一.
- 多变量逻辑回归模型评估了淋巴细胞数量和WMH/脑缩之间的关系.
主要成果:
- 与最低的四分位数相比,淋巴细胞计数最高的四分位数显示WMH,周周结节性高强度 (PVH),深白质高强度 (DWMH) 和大脑缩的风险明显较低.
- 在连续淋巴细胞计数和这些成像标记物之间发现了反向关联.
- 反向关联在轻度中风患者中对WMH具有重要意义.
结论:
- 基线淋巴细胞计数独立且反向地与AIS患者的WMH和大脑缩有关.
- 这一发现凸显了炎症在中风后CSVD标志物的发展中的潜在作用.
- 淋巴细胞计数可以作为AIS中大脑变化的预测生物标志物.
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