多囊卵巢综合征:标准,表型,种族和种族
1Department of Obstetrics and Gynecology Sapporo Medical University Sapporo Hokkaido Japan.
Reproductive medicine and biology
|January 23, 2025
概括
多囊卵巢综合征 (PCOS) 在种族和民族群体中呈现的不同. 识别像 hirsutism 和肥胖等症状中的这些差异对于准确的诊断和治疗至关重要.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 遗传学和基因组学 遗传学和基因组学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种异构的内分泌疾病,影响排卵,生育,代谢和心理健康.
- 在不同种族和种族的人群中,PCOS症状表现出显著的变化.
研究的目的:
- 审查PCOS在不同种族和种族群体的表型变异.
- 总结症状流行率和PCOS表型对不同人群的生殖和代谢特征的影响.
主要方法:
- 审查现有的关于PCOS患病率和症状表现在各种种族和种族群体的文献.
- 基于鹿特丹标准的PCOS表型分析及其与代谢和生殖健康结果的关联.
主要成果:
- 与其他群体相比,东亚人群的 hirsutism 和 adiposity 较少.
- 南亚,中东和西班牙裔人口的 hirsutism 的比例更高.
- 西班牙裔和非洲裔美国人更容易患肥胖和胰岛素抵抗.
结论:
- 临床实践必须纳入PCOS管理的种族和种族特异因素.
- 将PCOS诊断标准定制为种族和民族是防止错过治疗机会的关键.
相关概念视频
Oogenesis
63.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.4K
Pleiotropy
39.6K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
39.6K
Ovarian Cycle
959
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
959
Pedigree Analysis
83.8K
Overview
83.8K
Epistasis
45.6K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
45.6K
Stereotypes, Prejudice, and Discrimination
89.9K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
89.9K


