尿道节约性前列腺癌放射治疗:来自国际调查的当前做法和未来见解
Jennifer Le Guévelou1,2, Paul Sargos3,4, Piet Ost5,6
1Department of Clinical Research, Centre Eugène Marquis, Rennes, France.
Clinical and translational radiation oncology
|January 23, 2025
概括
前列腺癌放射治疗中的尿道节约技术可以减少尿道毒性. 专家推这些方法,特别是SBRT和再辐射,但对剂量限制缺乏共识.
科学领域:
- 辐射瘤学 辐射瘤学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医学物理 医学物理
背景情况:
- 在前列腺癌患者的尿道中高剂量的辐射与严重的生殖尿道毒性相关.
- 节约尿道的技术提供了一个有希望的策略,以减轻尿路的副作用.
- 前列腺癌的外部光束放射治疗 (EBRT) 需要优化剂量传递到关键结构.
研究的目的:
- 调查有关前列腺癌 EBRT 节约尿道的国际专家实践.
- 探索目前的全球实施和未来的尿道节约技术方向.
- 确定专家意见,定义尿道和尿道器官的风险,以及剂量限制.
主要方法:
- 一项由20个问题组成的国际调查分发给了26位专门从事前列腺癌EBRT的放射瘤专家.
- 23名专家参加了会议,提供了关于临床情景,危险器官定义和尿道剂量限制的见解.
- 数据收集的重点是目前的做法和专家对尿道节约策略的共识.
主要成果:
- 使用T2加权序列的磁共振成像 (MRI) 是尿道轮的首选方法 (83%的共识).
- 建议在前列腺癌的EBRT中进行尿道节约,除非瘤非常接近尿道或T4疾病.
- 虽然尿道节约在立体体辐射疗法 (SBRT) 和再辐射中更受欢迎,但在特定的尿道剂量限制方面存在显著差异.
结论:
- 尿道节约是一种有价值的技术,用于减少前列腺癌EBRT的尿毒性,特别是超低分离和SBRT再辐射.
- 在尿道剂量限制和节约技术方面缺乏共识,这凸显了对标准化的需要.
- 进一步的研究是必不可少的,以建立在前列腺癌放射治疗中节约尿道的标准化实践.
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