埃诺沙巴林静脉血栓塞栓症 预防 剂量 临界疾病 体重不足患者
Elizabeth Curcio1, Alyssa S Meester1, Angela Harding1
1OhioHealth Riverside Methodist Hospital, Columbus, OH, USA.
Hospital pharmacy
|January 23, 2025
概括
低体重患者服用埃诺沙巴林剂量在重大出血事件或VTE发生率上没有显著差异. 需要进一步的研究来确定最佳的VTE预防这群人群.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 血栓形成研究研究
背景情况:
- 在体重不足的患者中,最佳静脉血栓塞栓症 (VTE) 预防剂量尚未确立.
- 目前的证据不足以指导体质指数 (BMI) 低于18.5kg/m2的患者服用埃诺沙的剂量.
- 这项研究解决了在这个特定的患者群体中对VTE预防的数据的关键需求.
研究的目的:
- 为了比较接受不同剂量恩沙的低体重患者主要出血事件的发生率.
- 为了评估30毫克与40毫克每日皮下注射埃诺沙巴林在严重患有体重不足的成年人中进行静脉瘤预防的安全性和有效性.
- 确定在体重不足患者群体中预防VTE的最佳埃诺沙巴林剂量策略.
主要方法:
- 从单一医疗保健系统内的多家医院的数据进行回顾性分析.
- 纳入标准:成人患者的BMI<18.5 kg/m2,ICU入院时间≥48小时,并接受因氧沙巴林用于静脉瘤预防.
- 根据埃诺沙巴林剂量,患者被分为两组:每天服用30毫克一次或每天服用40毫克一次.
主要成果:
- 总共分析了310名体重不足的患者 (30毫克组80名,40毫克组230名).
- 在30毫克和40毫克埃诺沙巴林组之间,在重大出血事件发生率上没有观察到统计学上显著的差异 (P = 0.61).
- 包括VTE发病率,ICU停留时间,住院时间和30天全因死亡率在内的次要结局也显示,两组之间没有显著差异.
结论:
- 目前的证据表明,每天一次30毫克和40毫克的皮下注射埃诺沙巴林剂量导致体重不足,重症患者的临床显著出血率相似.
- 该研究没有发现两种埃诺沙巴林剂量策略之间的VTE发生率或其他关键临床结果的差异.
- 需要进行进一步的研究,以确定在体重不足患者群体中用于静脉瘤预防的最终最佳埃诺沙巴林剂量.
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