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Xuanji Wang¹, Michael Littau², Joseph Fahmy¹

¹Department of General Surgery, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60513, United States.

Surgery in practice and science

|January 23, 2025

概括

手术前的免疫营养没有改善胰腺癌患者接受胰腺双管切除术的结果. 在非癌症患者中,它与更长的住院时间和更多的感染有关.

科学领域:

手术瘤学手术瘤学
营养科学营养科学
胃肠病学胃肠病学

背景情况:

营养不良是胰腺二切除术 (PD) 患者生存率降低的一个关键因素.
评估免疫营养对PD结果的影响对于改善患者生存和康复至关重要.

研究的目的:

评估手术前免疫营养对PD患者停留时间 (LOS),感染率,术后胰腺 (POPF) 和延迟胃排空 (DGE) 的影响.
为了确定胰腺腺癌 (PDAC) 和非PDAC患者之间的免疫营养益处是否不同.

主要方法:

在2007年至2018年期间接受PD的344名患者的回顾性审查.
在接受常规饮食的患者与5天的手术前免疫营养之间的结果比较.
使用t测试和千平方测试进行统计分析,显著性设置为p < 0.05.

主要成果:

免疫营养显示增加了腹内感染 (23%对13%) 和POPF (19%对6%),但降低了DGE (8%对17%).
在PDAC患者中,免疫营养没有显著影响LOS,感染,POPF或DGE.
接受免疫营养的非PDAC患者经历了更长的LOS (12.4 vs 9.9天) 和更高的感染率 (26% vs 10%).

结论:

在手术前的免疫营养对接受PD的PDAC患者没有显著的益处,这些患者在LOS,感染,POPF或DGE方面经历PD.
接受PD的非PDAC患者的免疫营养与不良结果有关,包括更长的LOS和增加的腹内感染.
需要进一步的研究来确定PD患者常规免疫营养的疗效和安全性.

关键词:

延迟胃空化的时间.埃拉斯 (Eras) 是一个国际组织.免疫营养免疫营养免疫营养胰腺双切除术 (pancreaticoduodenectomy) 是一种切除胰腺的方法.手术后的胰腺.

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