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Updated: May 31, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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向B和T淋巴细胞减弱剂调节NZB/W小鼠中狼疾病的发展

Léa Gherardi1, Lucie Aubergeon1, Mélanie Sayah1

  • 1CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg, 67084, France.

ImmunoTargets and therapy
|January 23, 2025
PubMed
概括

向B和T淋巴细胞减弱剂 (BTLA) 显示在狼中具有治疗潜力. 在狼小鼠模型中,抗BTLA抗体治疗延迟了疾病发病,减少了脏损伤,并改善了生存率.

关键词:
这就是BTLA.抑制性受体的受体狼小鼠中的狼系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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