在折射器中使用口服双酸,在停止使用丹诺苏玛布后出现严重高血症
M E Bilici1, Z Siklar2, E Unal3
1Zonguldak Bulent Ecevit University School of Medicine, Department of Pediatric Endocrinology.
概括
德诺苏马布治疗后的严重高血症可以通过口服双酸盐有效管理. 这种方法减少了住院治疗,并控制了复发性,危及生命的高血症发作,特别是在儿童中.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 儿科 儿科 儿科
背景情况:
- 丹诺苏马布是一种RANK-L抑制剂,用于巨细胞骨瘤.
- 过血症,特别是断药后严重的反弹性过血症,是显著的副作用,特别是在儿科患者中.
- 治疗复发性高血症需要有效的治疗策略,以尽量减少并发症和住院时间.
研究的目的:
- 报告口服双酸盐在治疗后的严重高血症管理中的成功使用情况.
- 审查现有的关于在停止使用登苏马布后管理高血症的文献.
主要方法:
- 一个9岁的女孩患有巨细胞骨瘤的病例报告,在denosumab后经历了复发性高血症.
- 对于持续的高血症,初始治疗是IV双酸盐,其次是口服双酸盐 (阿伦德罗酸盐).
- 进行14个月的随访,以评估长期疗效和安全性.
主要成果:
- 口服双酸盐有效控制了复发性高血症,保持水平低于10.5 mg/dl.
- 在开始口服双酸盐治疗后的14个月随访期间,没有观察到过热血病发作.
- 口服双酸盐在长期管理中表现出有效性,减少了住院治疗的需要.
结论:
- 停止服用登苏马布后的反弹性高血症是一个重大问题,需要谨慎监测,特别是在儿童中.
- 口服双酸盐是一种可行且有效的选择,用于在denosumab治疗后长期治疗严重,复发性高血症.
- 这种方法可以显著减少患者住院治疗,并改善危及生命的高血症发作的管理.
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