系统性炎症反应指数与高尿素成年人中痛风的相关性:NHANES 2007-2018年
Xiaochan Tian1, Guixing Zeng1, Junping Wei1
1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in medicine
|January 23, 2025
概括
系统性炎症反应指数 (SIRI) 可能有助于预测高尿血症妇女的痛风风险,显示出显著的正相关性. 然而,这种关联在男性中没有发现,尽管在年轻人中观察到.
科学领域:
- 类风湿病学 类风湿病学
- 内部医学 内部医学
- 生物统计学 生物统计学
背景情况:
- 高尿路血是导致痛风的主要疾病.
- 鉴定患上痛风的高风险人群仍然具有挑战性.
- 系统性炎症反应指数 (SIRI) 与高尿血症患者的痛风之间的关联以前没有被研究过.
研究的目的:
- 为了研究SIRI和痛风在高尿血症患者中患病率之间的相关性.
- 评估SIRI作为痛风风险预测标记物的潜力.
- 将SIRI的诊断性能与其他炎症标志物进行比较.
主要方法:
- 利用了2007-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量逻辑回归,子组分析和平滑曲线拟合.
- 分析了日志2转换的SIRI值,并对共变量进行了调整.
主要成果:
- 在高尿血症女性中,SIRI与痛风患病率有显著的正相关性 (OR=1.385,p<0.001).
- 在高尿血症男性中,SIRI和痛风患病率之间没有发现显著的相关性 (OR=0.994,p=0.916).
- 在20-45岁的年龄组中观察到显著的正相关性 (OR=1.362,p=0.036).
结论:
- 在高尿血症女性中,SIRI显示出作为痛风风险的预测标记物的潜力.
- 在男性中,SIRI对痛风风险的预测价值可能有限.
- 需要进一步的研究来探索SIRI与不同年龄段的痛风患病率之间的关联.
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