慢性阻塞性肺病患者的循环维斯法丁度:系统性审查和元分析
Nahid Aboutaleb1, Alireza Moradi1, Hamzeh Mirshekari Jahangiri1
1Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Frontiers in medicine
|January 23, 2025
概括
这一系统性审查发现慢性阻塞性肺病 (COPD) 患者和健康人之间循环维斯法廷水平没有显著差异,尽管严重COPD的水平较低.
科学领域:
- 肺部医学 肺部医学
- 生物化学 生物化学
- 系统性审查和元分析
背景情况:
- 维斯法丁是一种阿迪波金,已与慢性阻塞性肺病 (COPD) 相关的炎症过程有关.
- 了解维斯法在慢性肺炎发病过程中的作用,可能有助于了解疾病机制和潜在的治疗点.
研究的目的:
- 与健康对照人群相比,系统地审查和元分析COPD患者的循环维斯法廷水平.
- 调查视沙丁水平与COPD严重程度和炎症标志物之间的潜在关联.
主要方法:
- 在Web of Science,PubMed/Medline和Scopus数据库中进行了全面的搜索,截至2024年3月.
- 包括的病例控制研究使用随机效应模型进行分析,以计算标准平均差异 (SMD) 和95%置信区间 (CI).
- 使用Cochrane Q和I2统计数据来评估异质性.
主要成果:
- 包括7项研究,包括265名COPD患者和244名对照. 综合分析显示,COPD患者的低维斯法丁含量趋势不显著 (SMD: -0.48 mg/L;95% CI: -1.67至0.70;p=0.43).
- 亚组分析表明,FEV1<50%和GOLD等级I-II的患者的视法丁显著降低.
- 相关性元分析显示,维斯法丁与IL-6 (p<0.001) 和TNF-α (p<0.01) 之间存在显著的关联. 超回归突出显示了与年龄,BMI,FEV1和IL-6的相关性.
结论:
- 循环中的visfatin水平显示,整体而言,COPD患者的患者数量下降不大.
- 进一步的研究是有必要的,以澄清visfatin的作用,考虑到跨研究观察到的异质性.
- 维斯法丁与炎症标志物和疾病严重程度的关联需要继续调查.
相关概念视频
01:29Assessment of Ventilation II: Respiratory Depth and Rhythm
2.9K
Respiratory Depth
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
2.9K
01:27Physical Assessment of the Respiratory Tract II: Inspection
1.4K
Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration...
Chest Configuration
The chest configuration...
1.4K
01:30Respiratory System Abnormal Finding I: Inspection and Percussion
1.2K
Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
1.2K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.0K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.4K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.4K
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
48
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
48