与甘油三糖指数和2型糖尿病风险相关的饮食模式:一项大型队列研究
Dong Liu1,2, Ziwei Liu1, Yue Wu1
1Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, China.
较高的甘油三糖 (TyG) 指数,表明胰岛素耐药性,与2型糖尿病风险增加有关. 特定的饮食模式高于黄油,肉类和土豆,低于蔬菜和鱼类,也会增加这种风险.
科学领域:
- 代谢健康 代谢健康
- 营养流行病学 营养流行病学
- 糖尿病研究 糖尿病研究
背景情况:
- 三甘油-葡萄糖 (TyG) 指数是胰岛素耐药性的验证标志物.
- 了解TyG指数,饮食模式和2型糖尿病 (T2DM) 之间的联系对公共健康至关重要.
研究的目的:
- 调查与TyG指数相关的饮食模式与发展T2DM的风险之间的联系.
- 为了确定与胰岛素抵抗标志物相关的T2DM风险有助于食物摄入的特定特征.
主要方法:
- 利用了来自120,988名参与者的英国生物库数据,进行了多次24小时的饮食评估.
- 使用降级回归 (RRR) 和LASSO回归来得基于TyG指数的饮食模式得分.
- 使用考克斯回归模型评估T2DM风险,平均随访时间为11.2年.
主要成果:
- 较高的TyG指数与T2DM风险增加有显著的关联.
- 两种不同的饮食模式出现了,它们之间有很强的相关性,其特点是摄入大量的黄油,肉类,果汁和土豆,而摄入少量的绿色蔬菜,油性鱼,酸奶,坚果,种子和干果.
- 这些饮食模式的最高五分之一显示T2DM风险显著增加 (HR为1.52和1.48).
结论:
- 提升的TyG指数和特定的饮食模式独立地与较高的T2DM风险有关.
- 以减少高风险食物摄入量和增加保护性食物为重点的饮食修改可能有助于减轻T2DM风险.
- 这些发现突显了代谢标志物和饮食习惯在T2DM发展中的相互作用.
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