实体瘤CAR-T细胞治疗中的伪进展:案例报告
Xuan Zhao1,2, Yanfen Liu1,2, Guohui Qin1,2
1Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in immunology
|January 23, 2025
概括
本案例研究描述了伪进展,一种暂时恶化的瘤,在一个老年患者的晚期胃癌治疗与仿真抗原受体 (CAR) -T细胞疗法. 这种现象的特征是最初的瘤扩大,其次是缩,为CAR-T细胞治疗提供了洞察力.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 晚期胃癌带来了重大的治疗挑战.
- 化学抗原受体 (CAR) -T细胞疗法是各种癌症的新兴免疫疗法.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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