螺旋计图案和心血管风险:对30万中国从未吸烟者的前性研究
Yinqi Ding1, Jingcen Hu1, Canqing Yu1,2,3
1Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
The Lancet regional health. Western Pacific
|January 23, 2025
概括
具有限制性螺旋计图案 (RSP) 或气流阻塞 (AFO) 的非吸烟者面临心血管疾病 (CVD) 的风险增加. 这些风险,特别是心力衰竭和肺部疾病的风险,在体重不足的个体中被放大.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 非吸烟者具有限制性螺旋计图案 (RSP) 或空气流阻塞 (AFO) 的心血管疾病 (CVD) 风险缺乏可靠的证据.
- 身体形状对这种心血管疾病风险的影响尚不清楚.
研究的目的:
- 调查RSP/AFO与从不吸烟者心血管疾病的各种结局之间的关联.
- 检查身体形状如何改变与RSP/AFO相关的心血管疾病风险.
主要方法:
- 利用了中国Kadoorie生物库 (CKB) 中从未吸烟者的数据.
- 雇佣的考克斯模型按性别分层 (278,953名女性,50,845名男性).
- 通过多个来源评估了基线上的螺旋计图案,并通过12年的中位数追踪了多个来源的心血管疾病结果.
主要成果:
- RSP和AFO都与急性心肌梗塞,其他缺血性心脏病,心力衰竭,肺心脏病,心律失常和脑内出血的风险增加有关.
- RSP也与缺血性中风相关. 风险随着AFO的严重程度而升级,FVC减少.
- 在体重不足的个体中,对特定心血管疾病的结局,如其他内脏病,心力衰竭和肺心脏病的相关性更为明显.
结论:
- 在非吸烟者中,RSP和AFO显著增加了各种心血管结果的风险,而不依赖于吸烟状态.
- 肺功能障碍的严重程度和体重不足状况加剧了这些风险,突出了呼吸系统健康,身体组成和心血管风险之间的关键相互作用.
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