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Updated: May 31, 2025

Transverse Aortic Constriction in Mice
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通过NEDD4介导的GSNOR降解加剧了心脏缩和功能障碍

Xin Tang1,2, Xiameng Liu1,2, Xinqi Sha1,2

  • 1Key Laboratory of Drug Targets and Translational Medicine for Cardio-cerebrovascular Diseases, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Jiangsu, China (X.T., X.L., X.S., Y. Zhang, Y. Zu, Q.F., L.H., S.S., F.C., L.X., Y.J.).

Circulation research
|January 23, 2025
PubMed
概括

调节后的NEDD4针对S-酸氨酸还原酶 (GSNOR) 进行降解,恶化心脏缩. NEDD4抑制剂在治疗心脏缩和心力衰竭方面表现有前途.

关键词:
在 Nedd4 泛素蛋白质连接酶中,Nedd4 泛素蛋白质连接酶是Nedd4 泛素蛋白质连接酶.心脏病巨大的心脏病.心脏衰竭是因为心脏衰竭.肌细胞,心脏细胞.无处不在的化

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