甲状腺激素释放激素神经的功能演变:来自皮的见解
Yingqiu Zheng1,2, Huachen Liu1, Xin Dang2
1The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, Shandong 266003, China.
Zoological research
|January 23, 2025
概括
甲状腺释放激素 (TRH) 通过激活受体并与胆囊托基宁 (CCK) 相互作用来调节海的食,以促进腹感. 这揭示了非状无脊椎动物中保存的神经信号.
科学领域:
- 神经内分泌学神经内分泌学
- 海洋无脊椎动物生物学
- 进化生物学 进化生物学
背景情况:
- 养行为由神经控制,甲状腺激素释放激素 (TRH) 在状动物中发挥作用.
- 在非带状动物养中,TRH与其他神经的保存和相互作用,如胆囊托基宁 (CCK),仍然在很大程度上是未知的.
研究的目的:
- 为了研究TRH信号系统及其在皮动物Apostichopus japonicus的食调节中的作用.
- 探索TRH在非状元动物中的功能性保存及其与CCK的相互作用.
主要方法:
- 生物信息分析和联结试验用于识别和表征TRH受体 (AjTRHR).
- 实验性给予TRH和RNA干扰 (RNAi) 来评估对养行为和CCK表达的影响.
- 对TRH类型的进化分析.
主要成果:
- 确定了一种功能性TRH受体 (AjTRHR),激活MAPK/ERK1/2信号通路.
- 在Apostichopus japonicus中,TRH的使用降低了食活动,并增加了CCK表达.
- 证实CCK和TRH是腹信号的协同组成部分,调解食抑制.
结论:
- 这项研究提供了一个TRH介导的信号系统的证据,在非状体中,特别是皮动物中.
- 这些发现扩大了对海洋无脊椎动物中神经调节的养机制的理解.
- 在食过程中,TRH信号在带动物之外的功能上保持不变,涉及与CCK相互作用以达到腹感.
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