单细胞与高密度脂蛋白的比率与动脉斑有关:一项回顾性队列研究
Shuang Liu1,2, Xinlei Miao1, Manling Hu3
1Health Management Center of the Second Affiliated Hospital of Dalian Medical University Dalian Liaoning China.
Journal of the American Heart Association
|January 23, 2025
概括
单细胞与高密度脂蛋白 (MHR) 的比率与心血管斑块 (CP) 风险有关. 较高的MHR水平显著增加了患CP和相关心血管风险的可能性.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- 单细胞与高密度脂蛋白 (MHR) 的比率是心血管疾病的已知指标.
- 冠状动脉斑块 (CP) 是心血管疾病的重要独立风险因素.
- 关于MHR与患CP的风险之间存在联系的证据有限.
研究的目的:
- 调查单细胞与高密度脂蛋白 (MHR) 的比率与发生动脉斑块 (CP) 的风险之间的关联.
- 评估MHR对大队伍中心血管风险的预测价值.
主要方法:
- 分析了大连健康管理队列 (2014-2022) 的5260名成年人队列.
- 根据基线MHR四分位数,参与者被分为四组.
- 用多变量调整的考克斯回归模型和日志等级测试来评估与MHR相关的CP风险.
主要成果:
- 在9725人年中,14.4%的参与者出现了新发性CP.
- 与最低四分位数组相比,最高MHR四分位数组的CP发生率显著更高 (101.5对每1000人年56.9).
- 在男性和女性中,MHR升高与CP风险增加 (HR 1.389) 和10年心血管风险增加有关.
结论:
- 升高的MHR显著与患上动脉斑块的风险增加有关.
- 监测和管理MHR水平可以帮助早期检测CP和心血管疾病的初级预防.
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