患有1型糖尿病的儿童是否仍然受到乙型肝炎的保护?
Pınar Yılmazbaş1, Diğdem Bezen2, Eren Vurgun3
1Department of Pediatrics, Health Science University, Prof Dr Cemil Taşcıoğlu City Hospital, Istanbul, Türkiye.
Journal of pediatric endocrinology & metabolism : JPEM
|January 23, 2025
概括
患有1型糖尿病 (T1DM) 的儿童对乙型肝炎疫苗接种的抗体反应降低. 建议在诊断时测试抗HBs血清学,并对血清阴性儿童进行再接种疫苗.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 1型糖尿病 (T1DM) 与免疫功能受损有关.
- 这可能导致免疫应对疫苗的免疫反应减弱,包括乙型肝炎.
研究的目的:
- 为了比较T1DM儿童的乙型肝炎表面抗体 (抗HBs) 血清学与诊断时的健康儿童.
- 在T1DM患者中调查与抗HBs水平相关的因素.
主要方法:
- 对214名T1DM儿童和210名健康儿童的抗HBs和乙型肝炎表面抗原 (HBsAg) 的回顾性分析结果.
- 群体之间的血清阳性率和几率的比较.
- 与抗HBs状态相关的临床和实验室数据的调查.
主要成果:
- 与健康对照组相比,患有T1DM的儿童的抗HBs血清阳性率和标位明显较低.
- 根据性别,BMI,并发症,自身抗体或脂质状况,没有观察到抗HBs状态的显著差异.
- 在抗HBs阴性T1DM患者中,观察到更高的诊断年龄和HbA1c水平,但在调整后,这些并没有显著改变血清阳性率.
结论:
- 被诊断为T1DM的儿童对乙型肝炎疫苗接种有较弱的免疫反应.
- 建议在T1DM诊断时进行常规的抗HBs血清学测试.
- 血清阴性T1DM患者应接受额外的乙型肝炎疫苗接种,以确保充分的保护.
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