纵向数据的多重推算:一个教程
Rushani Wijesuriya1,2, Margarita Moreno-Betancur1,2, John B Carlin1,2
1Clinical Epidemiology & Biostatistics (CEBU), Murdoch Children's Research Institute, Parkville, Australia.
Statistics in medicine
|January 23, 2025
概括
在纵向研究中处理缺少的数据需要考虑个别聚类. 多重归算 (MI) 方法必须与分析模型保持一致,但目前的方法很复杂. 本教程回顾了用于集群纵向数据的可访问MI技术.
科学领域:
- 医学研究方法学 医学研究方法学
- 生物统计学 生物统计学
- 纵向数据分析 纵向数据分析
背景情况:
- 纵向研究随着时间的推移收集重复的测量,需要分析方法来解释个人内相关的观察结果.
- 缺少数据是一个常见的挑战,特别是在纵向研究中,参与者 attrition 可以导致不完整的数据集.
- 多重归算 (MI) 是处理缺失数据的标准技术,但需要仔细考虑归算模型与分析模型的兼容性.
研究的目的:
- 对不完整的纵向数据进行现有多重推算 (MI) 方法的审查,特别是针对聚类个体.
- 强调在纵向研究中将归算模型与分析模型对齐的重要性.
- 为实施这些MI方法提供实际指导和可重复的代码 (R和Stata).
主要方法:
- 对适用于集群个体纵向数据的多重推算 (MI) 技术的审查.
- 讨论归算策略,包括将重复测量作为不同的变量,并使用一般化的线性混合归算模型.
- 使用R和Stata代码应用到现实世界的案例研究的说明性示例.
主要成果:
- 现有的MI方法用于纵向数据,虽然有效,但往往涉及复杂的数据操纵和先进的程序,限制其采用.
- 该教程表明,适当的MI技术可以在集群的纵向设置中成功处理缺失的数据.
- 有代码的实施指南有助于在医学研究中应用这些方法.
结论:
- 对纵向数据的准确分析需要推算模型,这些模型反映了个体内观察的集群性质.
- 尽管存在实施方面的挑战,但仍有可访问的MI方法用于处理不完整的纵向数据,从而提高了研究有效性.
- 这项工作提供了实用工具和审查,以鼓励在纵向医学研究中使用适当的MI技术.
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