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Updated: May 31, 2025

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
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In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity

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抑制剂试验用于在蛋白质链中分配功能性重要可访问站点:作为模型蛋白质系统的限制内核酶EcoRI

Joji M Otaki1

  • 1The BCPH Unit of Molecular Physiology, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara 903-0213, Okinawa, Japan.

Biotech (Basel (Switzerland))
|January 23, 2025
PubMed
概括

一种新的抑制剂测定 (PIA) 能够识别功能性重要的蛋白质位点. 这种方法有效地绘制药物开发和理解蛋白质相互作用的地点.

关键词:
这是EcoRI的EcoRI.药物设计 药物设计分子可访问性 分子可访问性和蛋白质工程是什么?这是一种抑制剂.蛋白质结构和功能 蛋白质结构和功能

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相关概念视频

Restriction Enzymes01:11

Restriction Enzymes

Restriction enzymes are bacterial enzymes used to cut DNA in a sequence-specific manner. To cleave DNA, they bind to specific palindromic sequences called restriction sites. Such palindromic DNA sequences or inverted repeats are commonly found in regions of functional significance, such as the origin of replication, gene operator sites, and regions containing transcription termination signals.
The host bacteria protect their own genomic DNA from these enzymes by methylating these sites. Some...
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