在COVID-19爆发后,虚弱的老年人功能状况下降和白蛋白下降:智利长期护理机构的描述性研究
Lidia Castillo-Mariqueo1, Alejandro Aedo Lagos2, Lydia Giménez-Llort3,4
1Carrera de Kinesiología, Departamento de Procesos Terapéuticos, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco 4780000, Chile.
Geriatrics (Basel, Switzerland)
|January 23, 2025
概括
COVID-19感染加剧了脆弱老年人的功能依赖,影响了日常活动. 较低的白蛋白水平和改变的红细胞沉积率 (ESR) 表明生理功能障碍,突出了针对性干预的必要性.
科学领域:
- 老年学是一门学科.
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 在老年人中,脆弱性很普遍,增加了对健康问题的脆弱性,特别是像COVID-19这样的病毒感染.
- COVID-19大流行不成比例地影响了长期护理机构中的脆弱人群.
- 了解COVID-19对脆弱个体的影响对于开发有效干预措施至关重要.
研究的目的:
- 评估智利长期护理居民在COVID-19感染前后的脆弱性,功能,认知和临床状态.
- 在这个人群中确定临床标志物,功能状态和脆弱性之间的相关性.
- 评估COVID-19对脆弱老年人的健康状况的影响.
主要方法:
- 一个单一中心,前后,相关性研究,涉及20名COVID-19阳性居民,共45名.
- 收集的数据包括人口统计,并发症,功能状态 (巴特尔指数,卡茨),认知状态 (迷你精神状态检查) 和生理资料 (血液学,脂质,生物化学).
- 皮尔森的相关性被用来分析变量之间的关系.
主要成果:
- 该队列主要由脆弱的老年女性 (平均年龄84岁) 组成,她们患有高血压和糖尿病等常见的并发症.
- 感染前,功能依赖 (巴特尔指数) 与脂质样本和红细胞沉积率 (ESR) 有负相关,与脆弱性指标有正相关.
- 感染后,功能依赖显著增加 (BI分数恶化),与脂质谱和ESR的相关性发生变化,白蛋白水平下降.
结论:
- 在脆弱的老年人中,COVID-19感染导致日常生活活动中的功能限制显著恶化.
- 降低的白蛋白水平和改变的ESR表明与感染/炎症过程相关的生理功能障碍.
- 需要有针对性的干预措施,白蛋白可以作为监测脆弱,感染个体的功能障碍的生物标志物.
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