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Updated: May 31, 2025

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety
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Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety

Published on: September 15, 2023

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作为人类单克隆抗体清除和生物可用性的预测模型的老鼠

Jason D Robarge1, Kevin M Budge1, Lucy Her1

  • 1Eli Lilly and Company, Lilly Corporate Center Indianapolis, Indianapolis, IN 46285, USA.

Antibodies (Basel, Switzerland)
|January 23, 2025
PubMed
概括

鼠标模型有效预测人类单克隆抗体 (mAb) 药理动力学,包括皮下生物可用性. 这为治疗性抗体发现提供了早期的,具有成本效益的评估,优于其他临床前模型.

关键词:
测量尺度缩放 (allometric scaling) 是指所有米尺度缩放的方法.生物可用性 生物可用性通过许可证的许可证.这是一种单克隆抗体.药物动力学 药物动力学鼠标 鼠标 鼠标 鼠标 鼠标

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