从疫苗菌株成分对抗体反应的现象学建模
Victor Ovchinnikov1, Martin Karplus1,2
1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Antibodies (Basel, Switzerland)
|January 23, 2025
概括
一个新的模型使用抗原序列和结合数据预测疫苗的疗效,帮助设计针对流感和SARS-CoV-2等可变病原体的疫苗.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 计算生物学 计算生物学
背景情况:
- 开发针对高度可变的病原体 (如流感,艾滋病毒,冠状病毒) 的疫苗需要产生广泛中和抗体 (bnAbs).
- 预测疫苗对各种病原体变异的疗效对于成功的疫苗设计至关重要,但仍然具有挑战性.
研究的目的:
- 根据抗原氨基酸序列和实验性抗体结合数据开发疫苗疗效的预测模型.
- 评估该模型在不同平台上对实验数据进行总结和预测疫苗性能的能力.
主要方法:
- 使用抗原氨基酸序列创建了一个简单的,具有生物动机的模型.
- 该模型与流感和SARS-CoV-2纳米粒子疫苗接种的实验性抗体结合数据进行了参数化.
- 该模型还应用于多价值mRNA流感疫苗接种研究.
主要成果:
- 该模型在实验不确定性范围内准确地回顾了实验抗体结合数据.
- 该模型表现出稳定性,对训练数据集相对不敏感.
- 结果表明,该模型可以预测抗原性表位,并间接表明接种疫苗的受试者中bnAbs的存在.
结论:
- 简单的数据参数化模型可以有效地预测和比较疫苗的疗效.
- 开发的模型显示灵活性和潜在适用于各种疫苗接种策略,包括纳米粒子和mRNA疫苗.
- 这种方法为优化疫苗设计提供了一条途径,以获得广泛中和抗体.
相关概念视频
Vaccinations
43.9K
Overview
43.9K
Antibody Structure and Classes
756
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
756
Antibody Structure
58.9K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
58.9K
Cross-reactivity
30.9K
Overview
30.9K
B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
Diversity of Antigen Receptors
497
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
497


