曼诺酸寡糖 通过操纵肠-大脑轴来改善实验性结肠炎和二次神经功能障碍
Shuang Lu1, Zhengxiong Tao1, Gan Wang1
1College of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan 430074, China.
Journal of agricultural and food chemistry
|January 23, 2025
概括
曼努酸寡糖 (MAOS) 通过调节肠道微生物群和抑制炎症途径来预防肠道和大脑疾病. 这些发现支持MAOS作为预防疾病的功能性食品成分.
科学领域:
- 我们的肠道微生物群.
- 神经科学是一个神经科学.
- 酸类寡糖化物
背景情况:
- 微生物群功能障碍与肠道和神经系统疾病有关.
- 曼努酸寡糖 (MAOS) 是一种酸寡糖 (AOS) 类型,在调节肠道微生物群和认知功能方面具有潜力.
- 肠-大脑轴中MAOS的精确机制和调节因素尚未完全理解.
研究的目的:
- 调查MAOS对肠-大脑轴 in vivo 和 in vitro 的影响.
- 确定涉及MAOS介导保护的关键监管因素和机制.
- 探索MAOS在预防大肠炎和神经系统疾病方面的潜力.
主要方法:
- 进行了体内和体外实验.
- 使用了德克斯硫酸 (DSS) 诱导的大肠炎模型.
- 我们分析了TLR4/MyD88/NF-κB信号通路.
主要成果:
- 预先治疗MAOS显著缓解了DSS诱导的大肠炎和二次神经损伤.
- MAOS 调节了血清中的 1,2-二米酸胆 (DOPC) 丰富度.
- MAOS抑制了TLR4/MyD88/NF-κB通路,影响了肠-大脑轴.
结论:
- 饮食MAOS在预防结肠炎和神经系统疾病方面发挥着至关重要的作用.
- 通过TLR4/MyD88/NF-κB通路调节肠-大脑轴,MAOS具有保护作用.
- 马奥斯显示出作为预防疾病的功能性食品成分的潜力.
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