用于集成到动态器官芯片上的凝应变传感器
Wenqi She1, Chong Shen2, Zaifei Xue1
1Key Laboratory of Biomass Chemical Engineering (Education Ministry), College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
Small (Weinheim an der Bergstrasse, Germany)
|January 23, 2025
概括
研究人员开发了一种高度敏感的水凝应变传感器,用于器官芯片 (OOC) 应用. 这种新型传感器可以实时监测芯片上的肺 (LOC) 系统,包括生理呼吸和炎症.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 微流体学 微流体学
背景情况:
- 目前的水凝压力传感器在水性细胞培养环境中缺乏灵敏度,这限制了它们与器官芯片 (OOC) 系统的集成.
- 开发敏感和稳定的应变传感器对于模拟动态OOC模型中的生理条件至关重要.
研究的目的:
- 开发一种新型,高灵敏的水凝应变传感器,用于集成到动态器官芯片 (OOC) 系统中.
- 为了证明传感器在肺上芯片 (LOC) 模型中监测生理和病理条件的能力.
主要方法:
- 通过在预先拉伸的,抗胀的水凝基板 (di-acrylated Pluronic F127和奇托) 上涂上一个MXene层来制造一个应变传感器.
- 在水凝传感器上培养膜上皮细胞,以形成膜屏障.
- 传感器细胞结构集成到动态肺上芯片 (LOC) 系统中.
主要成果:
- 制造的应变传感器表现出高灵敏度 (测量系数为290.96),广泛的传感范围 (0-100%),以及出色的可重复性.
- 传感器成功监测了LOC系统中的正常生理呼吸.
- 该系统有效地检测出由脂多糖 (LPS) 诱导的病理性炎症,并通过药物干预来缓解.
结论:
- 新型水凝应变传感器克服了以前的局限性,允许在动态OOC和LOC系统中进行敏感监控.
- 这项技术为研究肺生理学,疾病和药物反应提供了强大的工具.
- 传感器的高灵敏度和稳定性为先进的OOC应用开辟了道路.
相关概念视频
Observational Studies
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
Methods of Documentation VII: EMR
Electronic Medical Records (EMRs) primarily center around electronically documenting patients' health information within a single healthcare organization or practice. They contain essential clinical data related to a patient's medical history, diagnoses, medications, treatment plans, lab results, and other pertinent information relevant to the specific encounter or episode of care. EMRs are designed to streamline documentation and workflow processes within individual healthcare settings,...
Documentation in Long-Term and Home Healthcare Setting
Documentation in long-term care facilities and home healthcare settings is crucial for ensuring continuous, coordinated, and comprehensive care for patients. Each setting has its specific documentation processes and tools:
Long-Term Care Facilities
Long-Term Care Facilities
Introduction to Epidemiology
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...


