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使用碳基电极对特比纳芬化物进行选择性检测:用于制药产品的绿色和可持续的电分析方法

Isabelle de Oliveira Borges^1,2, Adriano Rogerio Silva Lima², Antonio Gomes Dos Santos Neto²

¹Universidade Federal de Santa Catarina, Departamento de Farmácia, 88040-900 Florianópolis, SC, Brazil. hellen.stulzer@ufsc.br.

Analytical methods : advancing methods and applications

|January 23, 2025

概括

这项研究引入了一种新的电化学方法,使用丝印碳电极 (SPCE) 和玻璃碳电极 (GCE) 进行精确的特比纳芬化物 (TBF) 量化. 开发的绿色分析方法为药品样本中的TBF测定提供了具有成本效益和敏感性的替代方案.

科学领域:

分析化学分析化学
电化学电化学电化学
绿色化学绿色化学

背景情况:

特比纳芬化 (TBF) 是一种重要的宽谱抗真菌药物.
准确,敏感和负担得起的分析方法对于制药中的TBF量化至关重要.
现有的方法可能缺乏成本效益或环境可持续性.

研究的目的:

开发和验证用于TBF确定的新型电化学方法.
首次探索使用丝印碳电极 (SPCE) 进行TBF量化.
为了比较SPCE和玻璃碳电极 (GCE) 对TBF分析的性能,并评估该方法的绿色凭据.

主要方法:

使用SPCE和GCE电化学测定TBF.
循环电压测量 (CV) 和电化学阻抗光谱 (EIS) 用于性能评估.
方波电压测量 (SWV) 优化,以提高灵敏度.
分析原材料和药片配方.

主要成果:

优化的SWV方法通过SPCE (LOD 1.48 μg mL−1) 和GCE (LOD 0.072 μg mL−1) 实现了敏感的TBF检测.
描述了TBF的电化学氧化,揭示了其机制和电极控制的过程.
该方法表现出与HPLC可比的高精度 (90-110%回收),并获得0.91.9的高绿色分析化学 (GAC) 评分.

结论:

提出的电化学方法,特别是使用SPCE,为TBF量化提供了灵敏,准确和具有成本效益的手段.
这种新的方法代表了用于制药分析的绿色分析化学的重大进步.
开发的方法是对TBF传统分析技术的可持续和可靠的替代方案.

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