升高的中性粒细胞与淋巴细胞比率预测了急性心肌炎的预后
Antonio Cannata1, Amitai Segev2, Cristina Madaudo3
1King's College London British Heart Foundation Centre of Excellence, School of Cardiovascular Medicine and Sciences, London, United Kingdom; King's College Hospital NHS Foundation Trust, London, United Kingdom.
JACC. Heart failure
|January 23, 2025
概括
中性粒细胞与淋巴细胞比率 (NLR) 升高表明急性心肌炎 (AM) 患者的预后更差. 这种炎症生物标志物可以帮助分层风险,即使在低风险个体.
科学领域:
- 心脏病学 心脏病学
- 炎症生物标志物 炎症生物标志物
- 临床预后 临床预后
背景情况:
- 中性粒细胞与淋巴细胞的比率 (NLR) 是心血管事件和死亡率的已知炎症生物标志物.
- 它在急性心肌炎 (AM) 的预后价值仍未评估.
研究的目的:
- 研究在被诊断为AM的患者中NLR的预后意义.
主要方法:
- 分析了来自10个国际中心的1,150名AM患者.
- 通过心脏MRI或内肌心脏活检确认诊断.
- 主要结局:全因死亡率或心脏移植;NLR切断点在4.
主要成果:
- NLR ≥4与预后较差相关 (P < 0.0001).
- 在调整后,NLR独立预测的结果 (HR:3.03;P = 0.010).
- 较高的NLR预测了低风险患者的更糟糕的结果,这些患者的喷射分数被保存.
结论:
- 升高的NLR意味着AM患者的预后更差.
- 对于风险分层来说,NLR很有价值,包括在传统的低风险群体中.
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