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Updated: May 31, 2025

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降低炎症体的关键组成部分:NLRP3 PROTAC 的发展

Tim Keuler1, Dominic Ferber2, Jonas Engelhardt3

  • 1Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany. guetschow@uni-bonn.de.

Chemical communications (Cambridge, England)
|January 23, 2025
PubMed
概括

研究人员开发了化向化马体 (PROTACs) 来降解NLRP3,这是先天免疫的关键蛋白质. PROTAC V2有效降低了NLRP3水平,为研究NLRP3炎症酶提供了一个新的工具.

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