西对健康志愿者的注意力和执行功能的急性影响:系统性审查和多层次元分析
P Yousefi1, Morten P Lietz2,3,4, F J O'Higgins5
1Cognitive Psychology Unit, Institute of Psychology, Leiden University, Leiden, the Netherlands. prs.yusefi@gmail.com.
Psychopharmacology
|January 23, 2025
概括
西会严重损害执行功能,显著减缓反应时间,但不会影响准确性. 这些认知效应取决于剂量,并因任务灵敏度而适度,影响安全的临床使用.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 认知心理学 认知心理学
背景情况:
- псилоцибин在神经精神疾病中显示出治疗潜力.
- 西对认知的急性影响,特别是对执行职能的影响,尚不清楚.
- 执行功能对于日常生活和治疗结果至关重要.
研究的目的:
- 量化psilocybin对执行功能和注意力的急性影响.
- 调查剂量,时间,认知领域和任务特征等调节者.
- 为了提供对神经化学机制和psilocybin的安全应用的见解.
主要方法:
- 对13项研究进行了系统审查和多层次元分析.
- 对执行职能任务的反应时间 (RT) 和准确性 (ACC) 的计算效果大小.
- 检查了调节者,包括时间 (90-180分钟后给药),剂量和任务灵敏度.
主要成果:
- 西显著增加了RTs (赫奇斯的g=1.13),但没有影响ACC (赫奇斯的g=-0.45).
- RT效应是剂量依赖的,并根据对执行功能的任务灵敏度进行调节.
- 发现了显著的异质性和出版偏差,但影响仍然显著.
结论:
- 西会严重损害执行功能,导致反应时间减慢.
- 这些发现强调了考虑认知影响对于安全的西管理的重要性.
- 讨论了潜在的神经化学机制和临床影响.
关键词:
准确度 准确度 准确度 准确度 准确度急性影响是急性影响.注意力 注意力 注意力 注意力认知表现 认知表现执行职能 执行职能 执行职能进行元分析分析.这种药物是psilocybin.迷幻药物 迷幻药物是一种精神药物.反应时间反应时间工作记忆 工作记忆更多相关视频
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