在接受放射-223治疗的患者中,Rn-219的呼气
Carsten Wanke1, Joerg Pinkert2, Lilli Geworski3
1Department for Radiation Protection and Medical Physics, Hannover Medical School, Carl-Neuberg- Str. 1, 30625, Hannover, Germany. wanke.carsten@mh-hannover.de.
在用二化-223 (Ra-223) 治疗的患者中,可以直接测量呼出的-219 (Rn-219). 这种方法准确地评估了患者的暴露,并且耐受性很好,证实了Rn-219在呼吸中的存在.
科学领域:
- 放射化学和核医学 放射化学和核医学
- 瘤学和癌症治疗疗法
- 辐射安全和剂量测量
背景情况:
- 二二23 (Ra-223) 二是一种已批准用于治疗具有骨转移的抗化前列腺癌 (CRPC) 的治疗方法.
- Ra-223的直接后代是-219 (Rn-219),一种放射性贵重气体,可以被患者呼出.
- 评估患者和潜在的家庭成员因Rn-219呼出而受到的辐射暴露对于门诊治疗安全至关重要.
研究的目的:
- 为了直接测量Radon-219 (Rn-219) 呼气在患者治疗二二化物-223 (Ra-223) 治疗.
- 评估Rn-219的直接呼吸测量方法的可行性和患者耐受性.
- 评估在门诊环境中潜在的辐射暴露风险.
主要方法:
- 使用了Alphaguard子监测仪和定制的呼吸测试套件,用于直接测量Rn-219在呼出的呼吸中.
- 测量是在注射后的两个时间点进行的:20-30分钟和3-4小时.
- 分析了14名患者的21次管理的数据,并将统计方法应用于受审查的数据.
主要成果:
- 在注射后3-4小时,呼出的气息中Rn-219活动度的平均值约为4.4kBq/L.
- 在注射后20-30分钟观察到更高的预期值,约为6kBq/L.
- 尽管测量范围有限,但统计分析证实了显著的Rn-219呼气.
结论:
- 使用Alphaguard仪器进行直接测量是评估Ra-223治疗患者的Rn-219呼气的合适方法.
- 测量程序被患者容忍得很好.
- 在呼出的气息中确认了Rn-219的存在,与间接测量结果一致.
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