疼痛性糖尿病神经病变与加速表观遗传衰老有关
Katarzyna Malgorzata Kwiatkowska1, Paolo Garagnani2,3, Massimiliano Bonafé4,5
1Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. katarzyn.kwiatkowsk2@unibo.it.
GeroScience
|January 23, 2025
概括
疼痛性糖尿病神经病变 (DN) 与加速的生物衰老有关. 这项研究发现,与无痛患者相比,疼痛性DN患者的表观遗传衰老和端粒缩短速度更快,这表明衰老可能会推动疾病的进展.
科学领域:
- 内分泌学和新陈代谢学
- 老年学是一门学科.
- 神经学 神经学
背景情况:
- 糖尿病神经病变 (DN) 影响高达50%的糖尿病患者,20%的患者经历神经病痛 (NP),造成重大负担.
- 虽然NP的危险因素在很大程度上是未知的,但过早衰老与慢性疼痛疾病有关.
- 基于DNA甲基化的生物年龄 (DNAm) 与疾病风险,发病率和死亡率相关.
研究的目的:
- 调查DN患者的大队伍中生物年龄和疼痛发展之间的关联.
- 为了比较表观遗传衰老标志物,端粒长度,血细胞计数和疼痛 (PDN) 和无痛 (PLDN) DN 患者之间的血蛋白替代物.
主要方法:
- 对99名PDN患者,132名PLDN患者和84名对照患者的6个DNAm生物标记子集的分析.
- 评估表观遗传年龄加速 (DNAmAgeHannum,DNAmGrimAgeBasedOnPredictedAge,DNAmAgeSkinBloodClock),衰老的速度 (DunedinPoAm) 和端粒的长度. 这是一个很好的方法.
- 预测血细胞计数和血蛋白替代物的评估.
主要成果:
- 与PLDN患者相比,PDN患者观察到加速表观遗传衰老,衰老速度和端粒缩短.
- PDN患者的预测血细胞计数发生变化,包括B淋巴细胞和T细胞减少,粒细胞增加.
- 在PDN和PLDN组之间发现了血蛋白替代物 (例如,GHR,MMP1,TGF-α) 的显著差异.
结论:
- 这项研究提供了第一个证据,将加速的生物衰老与痛苦的糖尿病神经病变联系起来.
- 这些发现表明,衰老过程可能直接导致PDN进展和2型糖尿病患者的整体健康状况下降.
- 用抗衰老药物准衰老过程可能会减缓或阻止疼痛性糖尿病神经病变的进展.
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