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一种全身成像技术,用于瘤特异性诊断和查B7H3向疗法

Lei Xia¹, Yan Wu², Yanan Ren³

¹Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China and.

The Journal of clinical investigation

|January 23, 2025

概括

一种新型的放射性追踪剂[68Ga]Ga-B7H3-BCH,有效地准B7H3过度表达的瘤,用于非侵入性成像. 这种药物在诊断和监测各种恶性瘤方面表现有前途,在临床研究中表现优于18F-FDG.

科学领域:

在瘤学瘤学.
放射化学放射化学是指辐射化学.
分子成像学分子成像学

背景情况:

B7H3 (CD276) 在人类恶性瘤中表达过度.
准B7H3可以实现B7H3表达性病变的普遍,非侵入性成像.
开发一种特定于B7H3的放射追踪器对于全身瘤评估至关重要.

研究的目的:

开发和评估一种新的B7H3向放射追踪剂[68Ga]Ga-B7H3-BCH,用于恶性瘤的PET成像.
在临床环境中评估诊断疗效和与B7H3表达的相关性.

主要方法:

优化B7H3定位附属体 (ABY) 来创建放射标记的标记物[68Ga]Ga-B7H3-BCH.
用B7H3转移的细胞进行体外研究和异种移植模型的体内PET成像.
临床翻译涉及20名患有恶性瘤的患者.

主要成果:

[68Ga]Ga-B7H3-BCH在表达B7H3的细胞和瘤中显示出高 afinity (KD=4.5nM) 和特定吸收.
临床PET成像显示了原发性和转移性病变中的标志物聚合.
与18F-FDG (81.7%) 相比,[68Ga]Ga-B7H3-BCH显示出更高的诊断疗效 (85.0%),并且与B7H3表达有很强的相关性.

结论:

[68Ga]Ga-B7H3-BCH是一种有前途的放射追踪剂,用于在全身恶性病变中非侵入性识别B7H3表达.
这种药物有可能改善治疗前评估,预测治疗反应和监测治疗耐药性.
特定于B7H3的PET成像可以预测瘤和周围组织中的B7H3表达水平.

关键词:

癌症癌症癌症癌症临床试验中的临床试验.发展发展发展发展发展分子诊断是一种分子诊断.在瘤学瘤学.

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