药物遗传学:我们所有人的研究计划和其他大型数据集的机会,以推进该领域的发展
Philip E Empey1, Jason H Karnes2, Julie A Johnson3
1Center for Clinical Pharmaceutical Sciences, School of Pharmacy; and Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;
Annual review of pharmacology and toxicology
|January 23, 2025
概括
药物遗传变异显著影响药物反应. 链接遗传和健康记录的大型数据集加速了药物遗传学研究和临床采用,克服了过去的翻译障碍.
科学领域:
- 遗传学 遗传学 是一个
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 药物遗传变异是影响药物的有效性和安全性的关键因素.
- 30年来,药物遗传学取得了重大进展,在过去15年中进行了临床实施.
- 药物遗传学在实践中的转化一直受到研究和验证方面缺乏全面数据的阻碍.
研究的目的:
- 审查药物遗传学发现到临床采用的阶段.
- 通过大规模数据倡议突出促进药物遗传学研究的机会.
- 讨论大型生物存储库在加速临床翻译中的作用.
主要方法:
- 审查在临床实践中实施的突出的基因药物对.
- 讨论来自大型队列与链接的遗传和电子健康记录的数据.
- 探索诸如我们所有人研究计划之类的倡议的潜力.
主要成果:
- 药物遗传学知识有了显著的进步,但数据的局限性使得临床翻译陷入停滞.
- 大规模的,集成的数据集 (基因组,EHR) 为发现和验证提供了新的途径.
- 具体的基因药物示例说明了临床采用的途径.
结论:
- 大规模的生物存储库和相关数据对于加速药物遗传学研究至关重要.
- 我们所有人研究计划和类似的倡议对推进个性化医疗有着巨大的前景.
- 克服数据差距对于药物遗传学的广泛临床实施至关重要.
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