一个皮层-亚皮层循环用于通过庞丁网状形成的运动控制
Emília Bősz1, Viktor M Plattner2, László Biró3
1Lendület Thalamus Research Group, HUN-REN Institute of Experimental Medicine, 1083 Budapest, Hungary; János Szentágothai Doctoral School of Neurosciences, Semmelweis University, 1083 Budapest, Hungary.
Cell reports
|January 23, 2025
概括
研究人员发现了一种新的皮层-亚皮层循环,涉及平行于基底腺 (BG) 电路的庞丁网状形成 (PRF). 这种新发现的运动控制途径会影响转向行为.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 皮质下电路 皮质下电路
背景情况:
- 运动和运动是由复杂的神经回路控制的,特别是皮质 - 基底腺 (BG) - 脑垂体循环.
- 虽然BG通过大脑干连接直接影响运动,但并行调节循环的存在在很大程度上仍未被探索.
研究的目的:
- 为了研究涉及运动调节的潜在的新型皮质-亚皮质循环.
- 阐明庞丁网状形成 (PRF) 在已知BG通路之外的运动控制中的作用.
主要方法:
- 目标是二级运动和带带皮层 (M2/Cg) 和它们的突出.
- 在PRF中研究了糖氨酸载体2-阳性 (GlyT2+) 细胞在PRF中的作用.
- 研究了PRF-thalamus通路对运动活动的连接性和功能影响.
主要成果:
- 证明M2/Cg皮层在PRF中强烈控制GlyT2+细胞.
- 表明PRF/GlyT2+细胞投射到并抑制乳头内膜/膜核 (IL/Pf).
- 发现这些PRF细胞的激活会诱导反侧转,这表明它在电机输出中发挥了作用.
结论:
- 庞丁网状形成 (PRF) 是一个新的皮层-亚皮层运动控制循环的一部分,与BG电路不同.
- 这种皮质-PRF-体循环可以调节转向行为,可能与BG通路协同作用.
- 确定了这种新循环用于运动调节的独特下降路径.
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