腹部内脏和皮下脂肪组织与绝经后乳腺癌发病率的关联
Jennifer W Bea1, Heather M Ochs-Balcom2, Celina I Valencia3
1Department of Health Promotion Sciences, University of Arizona, Tucson, AZ 85724, United States.
JNCI cancer spectrum
|January 23, 2025
概括
肥胖会增加绝经后乳腺癌的风险. 更高的腹部内脏 (VAT) 和皮下脂肪组织 (SAT) 与乳腺癌风险增加有关,而VAT/SAT比率提供了独特的风险估计.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 按体重指数 (BMI) 表示的肥胖与更年期后乳腺癌 (BCa) 风险增加相关.
- 腹部内脏脂肪组织 (VAT) 和皮下脂肪组织 (SAT) 和BCa风险之间的特定关联仍然不清楚.
研究的目的:
- 调查腹部VAT和SAT与患绝经后乳腺癌的风险之间的关系.
- 要确定增值税与SAT的比率是否为BCa提供了独特的风险评估.
主要方法:
- 一项前性队列研究对9950名绝经后没有癌症病史的妇女进行了27年.
- 双能X射线吸收计 (DXA) 扫描测量了基线,3年和6年脂肪度.
- 计算了竞争风险的多变量子危险比率 (SHR),调整了各种人口,行为,生殖和人类学因素.
主要成果:
- 较高的基线增值税和SAT与增加的BCa风险 (36%和19%分别) 有显著的关联.
- 增加的增值税/增值税比率与事件BCa.增加8%有关.
- 与增值税和增值税/SAT相关的最高风险在非洲裔美国人/黑人女性中观察到,尽管与其他群体相比,这一风险在统计学上并不显著.
结论:
- 增加的腹部VAT和SAT与更高的绝经后BCa风险有关.
- 增值税/SAT比率可以为BCa.a提供特定的风险指标.
- 需要对更大,更多样化的群体进行进一步的研究,以确认这些协会中潜在的种族和种族差异.
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