空气污染与骨关节炎风险和生存之间的关联和潜在的表观遗传变化:来自前性队列研究的见解
Jing Qian1, Jiahao Zhu1, Yifan Wang2
1Department of Epidemiology and Health Statistics, School of Public Health, Hangzhou Medical College, Hangzhou, China.
Ecotoxicology and environmental safety
|January 23, 2025
概括
长期暴露于空气污染会增加骨关节炎 (OA) 的风险,并恶化OA患者的生存结果. 表观遗传变化,特别是在GDF5基因附近,可能会影响这些效应.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的疾病,主要是未知的环境风险因素.
- 空气污染对OA发展和进展的影响需要进一步调查.
研究的目的:
- 调查暴露于各种空气污染物和发展OA的风险之间的联系.
- 检查空气污染暴露与OA进展,关节置换和生存之间的关系.
- 探索空气污染与OA关系中的潜在因果关系和表观遗传机制,包括DNA甲基化.
主要方法:
- 一项使用英国生物库数据的前性队列研究.
- 估计对颗粒物 (PM2.5,PM10,PM2.5-10),氧化 (NO2,NOx) 和空气污染暴露评分 (APES) 的暴露.
- 考克斯模型的应用用于生存分析,用于因果推断的全基因组关联统计,以及用于表观遗传修饰的基因环境相互作用分析.
主要成果:
- 对单个空气污染物的暴露与发生性OA的风险增加有关,但与OA进展到关节置换无关.
- 较高的APES与发生性OA风险增加9% (HR=1.09) 和OA进展至死亡风险增加16% (HR=1.16) 相关.
- 在GDF5基因附近的PM2.5相关CpG位点的基因预测甲基化与OA风险降低有关,这表明潜在的表观遗传作用.
结论:
- 长期暴露于空气污染与患上OA的风险更高有关.
- 空气污染暴露与OA患者的生存结果较差有关.
- 表观遗传修饰,特别是涉及GDF5基因,可能会调解空气污染对OA风险和结果的影响.
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