蛋白P预测急性呼吸障碍患者的死亡率
V Lindblom1, T Wessman1, P Wändell2
1Department of Emergency and Internal Medicine, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences Malmö, Lund University Malmö, Sweden.
Archives of gerontology and geriatrics
|January 23, 2025
概括
患有急性呼吸障碍的老年急诊室患者的低蛋白P (SeP) 水平与90天死亡风险更高有关. 测量SeP可以帮助初步患者评估.
科学领域:
- 生物化学 生物化学
- 老年病的医生 老年病的医生
- 紧急医疗 紧急医疗
背景情况:
- 良好的 (Se) 状态与更好的健康结果和较低的死亡率有关.
- 这项研究调查了状况,特别是蛋白P (SeP) 水平在预测死亡风险方面的作用.
研究的目的:
- 为了确定Selenoprotein P (SeP) 水平是否与在急诊室 (ED) 呈现急性呼吸障碍的老年患者的90天死亡风险有关.
主要方法:
- 考克斯回归分析用于评估从2013年至2018年招募的患者90天死亡率的危险比率 (HRs).
- 采用了两个模型:A模型调整了年龄,性别和其他因素;B模型纳入了A模型的统计学上显著的因素.
主要成果:
- 较低的SeP度独立地与90天死亡率的风险增加有关.
- 90天死亡率的危险比为0.798 (99% CI 0.678-0.940) 连续的SeP水平.
- 与最高四分位数 (99% CI 1.240-4.891) 相比,SeP最低四分位数的患者在90天内死亡的风险高出2.462倍.
结论:
- 低蛋白P (SeP) 度有效预测老年急诊室呼吸不良患者的90天死亡率.
- 对SeP水平的评估可以成为这些患者初步评估的宝贵工具.
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