新兴的替代品是否会给土壤带来与传统塑化剂相似的生态风险? 使用虫作为案例研究的多方面的分析
Huijuan Lv1, Baoyan Mu1, Haixia Xu2
1College of Resources and Environment, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Journal of hazardous materials
|January 23, 2025
概括
像DEHP及其替代品这样的增塑剂会导致氧化应激,并损害地的能量代谢. 这些化学物质还减少了地的繁殖,可能是通过类似雌激素的效应.
科学领域:
- 环境科学 环境科学
- 生态毒理学 生态毒理学
- 生物化学 生物化学
背景情况:
- 广泛使用塑化剂导致了环境问题.
- 像DEHP这样的酸盐很常见,但替代品正在出现.
- 了解这些化学物质的生态毒性影响对于土壤健康至关重要.
研究的目的:
- 研究DEHP,DEHT和ATBC对地的生态毒性影响.
- 为了阐明塑化剂诱导的毒性背后的机制.
- 评估生殖影响和潜在的内分泌干扰.
主要方法:
- 虫暴露于环境相关度的增塑剂.
- 测量活性氧物种 (ROS) 和脂质过氧化.
- 分析ATP含量以评估能量代谢.
- 评估生殖参数 (子,幼).
- 使用qPCR,AlphaFold2和分子对接来获得机械洞察力.
主要成果:
- DEHP,DEHT和ATBC诱导了显著的ROS积累和氧化应激.
- 所有测试的增塑剂都影响了能量代谢,降低了ATP含量43.2%-75.8%.
- 生殖能力显著下降,子 (23.3%-76.7%) 和幼 (24.2%-75.8%) 的数量减少.
- 对DEHP的替代品显示了类似于雌激素的效应,与生殖毒性有关.
结论:
- 塑化剂对健康构成重大风险,影响氧化平衡,能量代谢和繁殖.
- DEHP替代品的雌激素类活性是生殖毒性的关键机制.
- 结果为开发更安全的增塑剂和土壤生态系统影响评估提供了信息.
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