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在患有酒精使用障碍的男性患者中,下丘脑亚区域的结构和功能变化

Hyeonseok Jeong¹, Younghoon Chon², Sujung Yoon³

¹Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Drug and alcohol dependence

|January 23, 2025

概括

在酒精使用障碍 (AUD) 中,下丘脑亚区域的体积和功能连接性发生变化. 这些大脑变化,特别是在高级区域,可能会在持续的戒断中逆转.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
成研究研究成研究

背景情况:

下丘脑在压力和奖励处理中发挥着关键作用.
对酒精使用障碍 (AUD) 中的下丘脑亚区域进行的人类神经成像研究是有限的.
这项研究调查了患有AUD的个体的下丘脑亚区域体积和功能连接.

研究的目的:

为了检查AUD和健康对照个体之间的下丘脑亚区域体积的差异.
为了评估在AUD中的下丘脑亚区域的功能连接性 (FC) 改变.
探索这些神经成像标记物与与酒精有关的特征之间的关系.

主要方法:

在24名男性AUD患者和24名男性对照中使用了结构性和静止状态功能性MRI.
一个深度学习算法将下丘脑细分为五个子单元.
组之间比较了体积和FC,并分析了与酒精相关措施的相关性.

主要成果:

在AUD患者中,前上和结核上下丘脑子单元的体积减少.
在AUD的前上,前下和结核上子单元中观察到改变的FC.
较低的体积与更严重的疾病严重程度和较长的重饮史相关;较长的戒断与更大的体积和改变的FC相关.

结论:

特定的下丘脑子区域,特别是上层的,在AUD.中表现出改变.
这些神经成像发现表明,在长期戒断的情况下,下丘脑变化的潜在可逆性.

关键词:

酒精使用障碍使用障碍.功能连接性的功能连接性.下丘脑的下丘脑是什么意思磁共振成像技术磁共振成像技术亚区域子区域亚区域子区域时间量量量量

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