在帕金森病中,运动是否表现出对认知有剂量依赖的益处?
Joseph Seemiller1, Abhimanyu Mahajan2, Christopher B Morrow3
1Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA.
Parkinsonism & related disorders
|January 23, 2025
概括
通过身体活动快速评估 (RAPA) 测量的定期体育活动与帕金森病 (PD) 患者更好的认知功能有关. 即使是少量的运动也会带来好处,较高的活动水平与认知测试中的表现改善有关.
科学领域:
- 神经学 神经学
- 运动科学 运动科学
- 认知神经科学 认知神经科学
背景情况:
- 众所周知,帕金森病 (PD) 在运动症状和生活质量方面受益于运动.
- 在PD中,身体活动和认知表现之间的关系需要进一步研究.
- 现有的研究主要集中在运动的运动益处上,在理解运动对认知影响方面留下了一个空白.
研究的目的:
- 研究帕金森病患者身体活动水平与认知表现之间的关联.
- 为了确定在PD中运动强度和认知功能之间是否存在剂量依赖的关系.
- 用标准化测试来评估认知表现,与自我报告的身体活动相关.
主要方法:
- 利用身体活动快速评估 (RAPA) 来量化帕金森病 (PD) 患者自我报告的运动量.
- 通过符号数字模式测试 (SDMT) 和Stroop测试评估认知表现.
- 使用线性回归分析来检查RAPA分数与认知测试结果之间的关联,控制年龄和PD持续时间.
主要成果:
- 172名和181名参与者分别在药物"关闭"和"启动"状态下完成了Stroop和SDMT.
- 与没有运动相比,轻度的体力活动 (RAPA评分2-3) 与改善的SDMT和Stroop颜色命名性能相关.
- 较高的体力活动 (RAPA评分6-7) 显示出明显更好的SDMT和Stroop颜色命名性能比中等的活动 (RAPA评分4-5).
结论:
- 较高的自我报告的体力活动水平与帕金森病患者的增强认知表现有关,这取决于剂量.
- 在药物"关闭"和"启动"状态下都观察到认知益处.
- 即使是最低限度的体力活动也对认知产生了显著的积极影响,强调了开始运动的重要性.
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