整个基因组的转录基因组修饰和由金属有机框架引起的肺纤维化潜在危险
Yule Zhang1, Zhijin Yang1, Mengya Chen1
1Engineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, Shanghai Engineering Research Center of Environmental Biosafety Instruments and Equipment, University of Shanghai for Science and Technology, Shanghai 200093, PR China.
The Science of the total environment
|January 23, 2025
概括
金属有机框架 (MOFs) 显示出对环境的承诺,但MOF-199可能会损害人类支气管细胞. 这项研究揭示了MOF-199诱导细胞损伤和纤维化,需要对环境应用进行仔细的安全评估.
科学领域:
- 环境科学 环境科学
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 金属有机框架 (MOF) 为环境应用提供了卓越的性能.
- 然而,MOFs可能会带来健康风险,包括增加反应性氧物种 (ROS) 和炎症.
研究的目的:
- 研究MOF-199对人类支气管上皮细胞 (HBE) 的毒理影响.
- 阐明MOF-199诱导的细胞损伤背后的分子机制.
主要方法:
- 对暴露于MOF-199.9的HBE细胞进行转录组测序分析.
- 通过体外和体外实验验证实发现.
主要成果:
- MOF-199刺激导致ROS生成和细胞质Ca2+水平的增加.
- 观察到Grb2/SOS/Ras/Raf通路的激活.
- 通过TGF-β分泌,MOF-199诱导了HBE细胞亡和肺纤维细胞激活.
结论:
- MOF-199对HBE细胞产生显著的细胞毒性作用.
- 该研究强调,需要对在环境处理中使用的MOF进行严格的纳米安全评估.
- 这些发现强调了与MOF环境应用相关的潜在健康风险.
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